Thank you for this information. I'll be spreading the word. Animal Drug Safety Communication: FDA Alerts Pet Owners and Veterinarians About Potential for Neurologic Adverse Events Associated with Certain Flea and Tick Products, How to Report Problems with Flea and Tick Products, An official website of the United States government, : I gave this trash to my 5 month old JRT yesterday. I gave this Simparica Trio to my dog 2 days a ago, he is 7 days short of 14 yrs of age, He would not eat and drank very little for 2 days after giving this to him Never again want my Trifecta back had no problems, I gave my precious puppy this and 12 hours later, How long did your dog have dirreha duke his pill Monday and he hasnt had a normal poop. She hasnt eaten in 3 days and is unable to go up 2 simple steps. Yea so what about the 10 percent? I will never give my dog this medication again. Final Thoughts on Trifexis vs Simparica. I also changed him over to a raw diet a few weeks ago too have taken him off of this again to see if raw diet is causing it. Simparica is pretty new in England and it seems they are trialling it. And then when we finally stop for the evening - she crashes. I only researched it after he started not feeling well, just trusted my vet that this was safe. Vet office said make sure to give with food. Then she started having tremors. I hope this comment will save you and your pets from unnecessary trouble. my vet recommended this for both my yorkies. She was ok for awhile, then she had a seizure and started throwing up all over the house. Is it just me or does it seem like everyone is in this together? Simparico Trio, will not be given to my dog ever again. Sorry but keeping it caged due to a suspected side effect is is uncalled for. We have never had issues with him peeing in the house - EVER, and he peed in my office. They may not be ready to beat you in a game of chess, but these brainy dogs are easy to train and generally eager to please you. In about 3-4 days he threw up clear liquid, then went into spells where he coughed so hard it sounded like he was barking and screaming at the same time. I'll be calling them tomorrow. My poor baby! Thursday morning was an awful beginning of the day for our boy. I gave my 10 month old Yorkie the Simparica Trio dose provided by Banfield when she was spayed. Simparica may show slide side effects in a few dogs like tremors, unsteadiness, and/or seizures but else it is Tested and FDA approved suits to 90% of dogs. Lethargic and confused. I sure hope he makes it! All we want to do is take the best care of our animals and trust the people (Vet's) who specialize in this to do what's right for them. Hope all is well .my dog is 3,ive had him on Simparica trio for about 1.5 years and have noticed belly weight gain ,constant itching and some lethargy.his tounge hangs out of his mouth constantly which never happened prior to the medication .i have told my vet about these symptoms but they are quick to suggest its not related to the Simparica even though this all came about after putting my pet on this treatment.I decided last month to go against my vets recommendation and take my pet off the drug .maybe i put to much trust ij my vet and shouldve taken my dog off this drug sooner .better late then never .anyone suggest a tick and flea treatment less harmful for dogs ?? Lost all appetite. If she had just taken it they could give her Charcoal. I wish I would have came across this before I gave my healthy 9 month old puppy this medication two days ago. He is very friendly with other people and pets and never had an issue in that regard. Been also very lethargic not wanting to get out of bed. Furious that this out there for pets. We are beyond sad and livid! Both of them aren't eating like they were. Simparicaworks by impacting the nervous system of invertebrates such as fleas and ticks. This morning was the first morning he left water in his bowl. When fleas or ticks bite, they are exposed to its FDA-approved ingredient sarolaner, the insecticide, and acaricide that kills parasites fast. My vet never mentioned that puppies under 6months cannot be prescribed this medication. I should have kept with my gut feeling about any of these oral meds. And she keeps whining. As I said, the first was a week after taking it, then the 2nd and third seizure happened at day 29. This may post twice - I didn't see my original post so I'm trying again! My husband said , get dressed were taking him in . No way I will ever give it to her again. I would say these changes may have happened more suddenly than just normal aging so I'm not going to give him this medication anymore. Is Simparica only available with a prescription? Took a dose of simparica trio.second rose in second month.dog is having tremors. Her last dose of Simparica Trio was given to her on October 1, 2021. And urinating more often as a result. I will never use this stuff again and will tell anyone I see buying it or using it my story and yours too. This is terrible. Then they come back! Apparently many pet owners lack the critical thinking skills it takes to fully reason this out. I PRAY that our baby is okay with this second dose. Started giving my dogs Simparica Trio 5 months ago didn't put together the changes in the one dogs personality until today within a couple of weeks she would all of a sudden go from a loving dog to attacking the other dog it is getting worse. I'll tell you what I can meningitis is the swelling of tissue surrounding the brain and spinal column and can be cause by either bacteria or a virus. Simparica Trio Recall can be trusted with their product. The study also established safety: Simparica Trio was well tolerated by the dogs, even in the presence of concomitant medications, with adverse effects mild and minimally occurring. If she continues I will be going to the vet. Animal Health Literacy, Recalls, Market Withdrawals and Safety Alerts, Fact Sheet for Pet Owners and Veterinarians about Potential Adverse Events Associated with Isoxazoline Flea and Tick Products, How to Report Animal Drug and Device Side Effects and Product Problems. My vet seems skeptical that this is related to simparica but it seems clear to me, although I realize that anecdotal cases don't prove it. Possible Side Effects. This medication works within the first few hours after administration to kill fleas present on your dog, and is dosed by weight, so it is important to use the correct-sized medication for your pet. Hi how is your pup now? What number do we call for FDA? They want to test him for the MDR gene, put him on fluids and I have to take him in tomorrow for more fluids but he is not improving. Getting him to go out was nearly impossible. Is the added expense worth the trouble to insure your beloved pet? Those incidents are still under investigation because the numbers of report are extremely low. He never ever used to do this. Will not use this again and will warn others. Fortunately, no seizures but dark yellow diarrhea and puppy has been drinking water like crazy and peeing even while asleep. My dog has had 3 seizures in the past from wearing a flea collar. They think its a spinal disease thats causing a lot of his symptoms and sent him home with four meds, I need to keep him totally calm, no playing, running etc. I have paid about $500 - $600 to heal the little King, but it's not working. Charlie took the pill on Monday and could not even walk this morning. However, since on the market there have been thousands of reports of seizure in otherwise healthy dogs. It comes as the first choice when prescribing a treatment due to its liver flavor. Made the pressured in to by a vet to give Simparica Trio. However a spinal tap of the fluid surrounding the spinal cord would be need to prove your dog indeed has spinal meningitis and then to treat for the specific bacterium or viral causes. First month, the one threw up, same thing second month. She has had tremors, very lethargic, drinking lots of water. The seizure and tremors are side effects after consuming some drugs that's mixed with this one. I gave my dog simparica at 10:15am. It sounds as if she's been pinched while sleeping although nothing visible happened. Poor baby has had vomiting and diarrhoea ever since. I say yes! Certain age, breed predispositions. I would not recommend giving Simparica to your pets!!!!! It is better but not gone. No diarrhea or vomiting or seizures. Haven't noticed any other symptoms to him besides the puking, not eating and skittish. I would absolutely rather be safe than sorry.. no more simparica trio for that guy. I was furious with the drug and the prescriber too. Didnt notice anything with first dose. (toy aussie & corgi). We rushed him to the emergency vet and they put him on keppra to stop the seizures. He slowly recovered over 3 weeks until he is just now starting to return to normal activity level. I can tell something is off with her I just couldnt figure it out. So I did. I gave simparica trio to my 10-year-old Havanese. . The revolutionary chewable tablet - Simparica is highly effective in eliminating fleas and various types of ticks. We are doing one more increase and if that doesnt help, we will be adding zonisamide. gave this to my dog three different times. Doctor prescribed the salyien with some injunction but all are in vain..my labrador has same issues till datemy vet.not says anything about the side effect of the Simparica..i m now helpless..pls help me what should I do.. please help me to rid over itpls pls ..guide me. Lone Star, deer, and American and brown dog ticks to prevent up to 15 tick-borne diseases in dogs. Pyrantel only treats parasites found in the gastrointestinal tract because it does not absorb well into the bloodstream. It's definitely not! He has trouble raising his leg to urinate. There is a petition in Australia to have this drug banned through change.org, which I've signed. We rescued another dog. Simparica is approved for dogs and puppies weighing more than 2.8 pounds and over 6 months of age. Im really trying to understand the science behind what is happening to my puppy and the vet, neurologist, drug company have been little help. Pharmaceuticals are killing people and pets, Pet Bucket Ltd is a UK registered company|Company no: 08345021|BTC Bessemer Drive Stevenage, SG1 2DX UK. My dog is having seizures. I'm sick, gave our 8 week old aussielabradoodle her 1st dose of the trio yesterday and the poor baby has had diarrhea 4x so far. my puppy was prescribed this and now is weeing more often than usual and still itching ! I took him back to the vet and explained my concern that it was from the Simparica Trio and they didn't seem concerned that it was the issue. We gave our 3.5 month old Aussie pup a dose of Simparica today (vet's prescription), and I did not see the warnings about giving it to dogs under 6 months. My 14 year old, 3.5 lb Chihuahua (picture the tan colored Taco Bell Chihuahua, identical) received a tablet that I cut in 4 pieces and buried in his food. I rescued a dog that had a light case of heartworms. Never again will I be giving my pets any pharma meds. Im done with this drug! Our vet gave us this medication for our 8 week old Great Dane puppy. I will not be continuing with this treatment. I gave this to my 8 yr old chihuahua and a couple days later he started having seizures. Other signs may include: Contact your veterinarian if you notice these or other signs of illness after giving Simparica Trio to your dog. Is there any good outcomes from this tablet? They were ok on that but the vet office is no longer going to carry regular Simperica so we took the Simperica trio that is now in its place. By overloading chloride into these worms, it affects the electrical activity within their nervous system, causing muscle paralysis and death. That night he seemed a little uncomfortable, unable to sleep, and I didnt think anything of it. I am so beyond mad, what can I do to get this out of her system and better yet what can we do to get this product off the market. He loves the taste of Simparica Trio and it's like a treat for him. Advised I could call Simparica for reimbursement or to report side effects. 24 hours after, we noticed diarrhea. I called our Vet on the second day and they said they doubted very seriously that the Simparica would have give him diarrhea, and then told me that I should wait and see what happens with the next dose, because I had also told them that he had some drippings from some ground beef over his dog food the day before I gave him that first dose. Pyrantel only treats parasites found in the gastrointestinal tract because it does not absorb well into the bloodstream. Has anyones dog stopped having seizures when the medication wore off or is this going to be a permanent issue possibly getting worse? Simparica has caused my 12 pound 5 year old Jack Russel Terrior mix to have leg tremors and have trouble walking, jumping, or running. Next day she seemed different, standing slightly strangely. Anything I can do for him? I have every intention of calling and filing a complaint. None of our pets did they were healthy. Simparica Trio also contains the ingredient moxidectin, which shifts chloride, a naturally occurring electrolyte, across the cell membrane of certain susceptible worms such as heartworms, roundworms, and hookworms. before i even gave to my dog small doxie i asked the vet about it and they assured me it was safe since she was and i say was a healthy dog. I took him to the emergency hosp. Hi there, my dog has been taking simparica trio for two months. They recommended I hospitalize my dog immediately as it's a concern and he's currently there receiving IV fluids, meds, and after an ultrasound is now receiving medication for possible liver infection. It hurts to see this and infuriating to know these stories are out here and we did not do the research before giving our little guys this poison. Use with caution in dogs with a history of seizures or neurologic disorders. I did and they said they are going to report it to the FDA. However, your dog must have a history of negative test results for these diseases. Two quick questionsDo the dogs eventually return to normal? Your veterinarian may recommend a heartworm test if you are using Simparica Trio. For Instance he has never liked grooming, I brushed him out last night and he slept through the whole thing. He also would have crying spells while trying to sleep but showed no signs of pain. He has been very healthy, and it does not seem to bother him, but it is becoming more noticeable recently. My 3 other poodles unaffected. I have a person that bought a husky puppy from me March 6 @ 6 weeks old. The doctor did blood work and gave him steroids and said to watch him carefully for the next few days. While veterinarians often prescribe medications for off-label uses, your veterinarian will determine whether Simparica is right for your pet. https://photos.app.goo.gl/GbP8UmDNBAxJ1m4g8 I feel like we are just waiting for him to pass now. We gave our one year old Simparica tonight and he started having trimmers that lasted on and off for about 30 minutes. The vet said the simparica didn't cause the disease but it could have been the link that pushed him into the Crisis. Gave my 28lb German Spitz her monthly prescibed dose of Simparica. I thought the first one it happened to may have gotten something in her eye but then a few days later the other had the same issue. , My healthy six years old heidi also passed away after given simparica by her childhood vet causing seizures which got so bad u cudnt keep a count follower hy liver failure.dont give ny tick fleas medication orally. So just be very careful with whatever you give your little one in the future. I gave my 5m old pup this drug - she collapsed in the evening and was unable to walk. I wish I could get this out of her system now. So the next day was Saturday , me & my husband got up early . In some dogs, Simparica may cause abnormal neurologic signs such as: Tremors and Seizures. He already has canine dementia on and off. The ONLY thing that could cause such a huge change in behavior and personality had to be giving him the Simparico Trio the previous week. This went on for 4 hours. Did you ever get to the bottom of redness in eyes? She became extremely lethargic and feverish so we rushed her to Hospital. It wasnt even four hours later all four of my dogs were throwing up, lethargic sick as hell didnt think they were gonna make it three pulled out my little Mr. weenie. Reading all these similar cases cant figure out how the hell this crap is still being prescribed. Other signs may include: Lethargy Loss of appetite Could use of Simparica be related to increased prevalence of mast cell tumors in dogs? After reading all these reports I am convinced this is the reason our baby is so sick. she has shaking off and on . I went and picked her up today and all she does is lay around and drink water, turns her nose up at anything food related. I had a trainer come in the day of, and he was with me the all day, NOTHING a happened for him to be in pain! I gave my six-year-old dog SIM perica because the combo guard was on back order. But today, after he ate dinner and drank water, it all came back up. In such cases, please visit the veterinarian as soon as possible. She has not had any of the reactions everyone seems to be describing but she had respiratory distress. Same here! Simparica Trio is safe to give in conjunction with most other medications, but be sure to tell your vet about all medications and supplements you give to your dog. Many people have reported this as only temporary. The diarrhea also went away yesterday evening. If it was due to the Simparica, then it would expected to be resolved within a day or two. I called the vet and she gave me anitdiarrhea medicine. I can not find any information on a delayed reaction AND my Vet just discredits that its the Simparica because my dog goes to Daycare and could be exposed to other mystery things. . Hi, how long it took for the diarrhea to go away. She would constantly twirl in left circles. They gave him a strong shot of prednisone that was good for 2 days . Yes, she was still having seizures! We got to the Animal Hospital . This time he just kept collapsing, bloated appearing, vomit, and diarrhea, and hiding with his face down and nose in carpet. Today she has fallen 2 or 3 times in the last 8 hours). Got a new GS when the old one died. We asked our vet, but he ignored the question. My vets comment was I would know if his symptoms were related if at time for next dose his symptoms were gone they are gone. After your dog takes the chew, the drugs circulate in the blood, and when a flea or tick bites your dog, it's exposed to the chemical. This is taken from the article printed above all these comments "Simparica works by impacting the nervous system of invertebrates such as fleas and ticks. It is Now 3 pm and Lily is on her way to the animal hospital and most likely going to have to spend the night, we will flush her with iv and hope It helps Flush It out Of her system. If there are enough reports they may have to pull it off the market until further safety tests can be done. She has been the healthiest, happiest dog. Nothing. She also started with ear infections. She also started drinking excessively, and peeing in the house. She had been on the Seresto collar and Tri-Heart for 8 years with no issues. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. Can anyone tell me how long it takes for meds to be completely out of system? The vets could not exactly pinpoint what had cause her the sudden effusion and seizures. Eight hours later and she has terrible diarrhea and vomiting, now she is not eating. So scary. This is so awful. Prednisone helped symptoms in our case but the seizures kept going even after stopping this horrible med. Im worried sick. Possible side effects: Vomiting, diarrhea (if these . I notified my vet and Zoetis, the company that makes this drug. I hope and pray for no long term affects. And how do we get the word out to everyone? Linda. It seems to coincide with the monthly dosage. She didn't make it to the next day and died overnight. My best friend's new puppy has had diarrhea for 14 days after taking one dose of Simparica. This drug needs to be pulled off the market! But the wandering and "head pressing" it's called, where they just go into the corner or lean against a table leg or the wall. In clinical trials, vomiting and diarrhea were the most frequently reported adverse reactions. How can you give a dog a pesticide to ingest. I lost my previous bichon poo to seizures 2 years ago and I dont want to go through that type of pain and lost again! Do you have contact details that you can share with me. She will not get this anymore. Now do you get the connection? She vomited twice and became so lethargic that she couldnt walk. On her 3rd round of antibiotics (each a different kind) and completing prednisone. Seriously I have had the worse luck. Now her dog is very sick and she has to take the dog to the vet every day in the past week. I feel like this drug was pushed by my vet tech and veterinarian. Puppy Simparico Trio for the first time 2 days ago. Hi, how much charcoal did you administer? You don't think I'm going to continue with this poison. Was not too excited about it, and I really should've declined it. You seem like an idiot. I came across this site and read so much about symptoms that I now realize he has been having. She is only 6 and was so full of life and energy. #JusticeforCassie My thoughts and prayers are with you all as I go through the same thing with my beautiful Cassie girl. Follow the directions on the drug label for Simparica or Simparica Trio or as provided by your veterinarian. Mine has tremors once in a while and now I know why! Only some dogs show this symptom. I find it odd that this was around the time she was due for her next dose that she didn't get for obvious reasons. My 3 month old shih tux Juno took her second dose last week and for the last two days shes vomited and has been eating grass nonstop! She was due to get the next dosage this week and i am choosing not to give it to her with the hopes that it will be out of her system and her Liver levels will go down. CET HEXtra Chews. Will never use again. Skin issues. I feel horrible for listening to the vet without researching this on my own. On the first day he woke up and peed in my bedroom floor. It's getting better and I decided to just wait and hope when this stuff clears out in 30 days he goes back to normal. Some dogs, Simparica may cause abnormal neurologic signs such as fleas and ticks were. Go away they said they are going to the bottom of redness eyes! 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